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Has antiplatelet effect. It is the weakening or disappearance of pain rheumatic and rheumatic character including pain in the joints at rest and during movement, reduces morning stiffness and swelling of joints, increases range of motion; in inflammatory processes that occur after surgery and injuries quickly facilitates both spontaneous pain and pain on movement and reduces inflammatory swelling at the wound site. After oral administration of a single dose of 25 mg or 50 mg is rapidly absorbed, T max ; about 2 hours; when using rectal absorption rate is higher. If nine hours daily intake of 25 or 50 mg of Indomethacin three times daily average equilibrium concentration 1.
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Biotransformiroetsa mainly in the liver. The plasma is in the form of unchanged substance and desmethyl -, desbenzoyl — and desmethyl — dezbenzoilmetabolitov present in an unconjugated form. It passes through the BBB. Not removed by hemodialysis. When the instillation of eye drops enters the anterior chamber of the eye. After a single instillation is determined by the moisture front of the camera within a few hours. In carcinogenicity studies in rats study period ; 73 — weeks and mice study period ; 62 — 88 weeks at doses up to 1.
There were no mutagennocti indomethacin in some bacterial tests in vitro Ames test, the test with E. In the reproduction studies, including two generations, at dose levels up to 0. Rectally Inflammatory and degenerative diseases of the musculoskeletal — musculoskeletal system: Algomenorrhea, to maintain pregnancy, Bartter syndrome secondary hyperaldosteronism , pericarditis symptomatic treatment , childbirth as analgesic and tocolytic agent in preterm labor , inflammation of the pelvis, including adnexitis, cleft arterial duct. Infectious — inflammatory diseases of ENT — organs with marked pain syndrome in the complex therapy: For topical use for application to the skin due to traumatic inflammation of the tendons, ligaments, muscles and joints due to strains, sprains, and bruises after the load.
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Inflammatory and degenerative diseases of the musculo — skeletal system deforming osteoarthritis, rheumatoid arthritis, psoriatic arthritis, rheumatoid arthritis, frozen shoulder, ankylosing spondylitis, low back pain with radicular syndrome except for degenerative disease of the hip joints. In ophthalmology eye drops: In dentistry systemic and cutaneous application: Contraindications for systemic use: Restrictions on the use For cutaneous application.
In ophthalmology eye drops. Application of pregnancy and breastfeeding Teratogenic effects of teratogenicity studies conducted in rats and mice at doses of 0. Comparative study in rodents using high doses of aspirin showed similar effects in females and their fetuses. However, reproductive studies in animals do not always predict effects in humans.
Adequate and well-controlled studies in pregnant women have not done. Vascular system of the fetus premature closure of the ductus arteriosus , the use should be avoided during pregnancy especially in the later stages.
Indomethacin | C19H16ClNO4 - PubChem
It was observed increase in the incidence of neuronal necrosis in the diencephalon in live births fruit. At a dose of 2.
Introduction 0. Category effects on the fetus by FDA ; C. Indomethacin passes into breast milk, so breast-feeding should be discontinued during treatment and avoid the use of indomethacin during breastfeeding. The liquid and suppository forms of Indocin may be stored at room temperature. Keep both forms from extreme heat, and protect the liquid from freezing. What side effects may occur? Side effects cannot be anticipated. If any develop or change in intensity inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Indocin.
If you are sensitive to or have ever had an allergic reaction to Indocin, aspirin, or similar drugs, or if you have had asthma attacks caused by aspirin or other drugs of this type, you should not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced. Do not use Indocin suppositories if you have a history of rectal inflammation or recent rectal bleeding.
Special warnings about this medication Indocin prolongs bleeding time.
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If you are taking blood-thinning medication, this drug should be taken with caution. Your doctor should prescribe the lowest possible effective dose. The incidence of side effects increases as dosage increases. Peptic ulcers and bleeding can occur without warning, especially in people over This drug should be used with caution if you have kidney or liver disease, and it can cause liver inflammation in some people.
Do not take aspirin or any other anti-inflammatory medications while taking Indocin, unless your doctor tells you to do so. If you have heart disease or high blood pressure, this drug can increase water retention. This drug can mask the symptoms of an existing infection. Indocin may cause you to become drowsy or less alert; therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended.
Indocin may also cause confusion and, rarely, psychosis, especially in older adults. Possible food and drug interactions when taking this medication If Indocin is taken with certain other drugs, the effects of either could be increased, decreased or altered. It is especially important to check with your doctor before combining Indocin with the following: Aspirin Beta-blockers such as the blood pressure medications Tenormin and Inderal Blood-thinning medicines such as Coumadin Captopril Capoten.
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Asymmetric Unit. Macromolecule Content Total Structure Weight: This is version 1. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. Flanagan, J.
Hide Full Abstract. Protein Feature View. Small Molecules.