During the last decade, their occurrence in the environment and human food chain has been studied only to a limited extent. Unfortunately, complicated analytical methodology at present hampers a regular and adequate human and environmental exposure assessment. For this reason, the available data for fish and wildlife were evaluated for possible inclusion in the WHO-UNEP TEF concept, along with the chlorinated congeners as published earlier van den Berg et al.
For this purpose, only REPs from fish larvae studies are available for the brominated compounds.
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These indicate that there may be significant differences between the SARs of REPs for fish early life stage toxicity for both brominated and chlorinated congeners. Instead, it is recommended that regulatory agencies consider the use of REPs provided in Table 1 for the use of ecotoxicological risk assessment in the aquatic environment. This is comparable to the inherent uncertainty of one order of magnitude in the present WHO TEF approach for dl-like chlorinated compounds.
Based on the considerations discussed above, the use of similar interim TEF values for brominated and chlorinated congeners for human risk assessment is recommended by the WHO and UNEP, pending availability of future studies on these compounds. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Article Navigation. Close mobile search navigation Article Navigation.
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Contaminants in fish tissue from US lakes and reservoirs: a national probabilistic study
E-mail: m. Oxford Academic. Google Scholar. Michael S.
CLARC - Washington State Department of Ecology
Linda S. Michael J.
Heidelore Fiedler. Jerzy Falandysz. Martin Rose. Dieter Schrenk. Stephen Safe. Chiharu Tohyama. Angelika Tritscher. Mats Tysklind. Richard E. Cite Citation. Permissions Icon Permissions. Open in new tab Download slide. Table 1. Open in new tab. Search ADS.
The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls. Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice. Absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin TCDD after low dose dermal exposure. Brominated dioxin-like compounds: In vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds.
Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. Google Preview. Polybrominated dibenzo-p-dioxins, dibenzofurans, and diphenyl ethers in Japanese human adipose tissue. Regulation of cytochrome P Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners.
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