Toxicological profiles - Chlorinated dibenzo-p-dioxins

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During the last decade, their occurrence in the environment and human food chain has been studied only to a limited extent. Unfortunately, complicated analytical methodology at present hampers a regular and adequate human and environmental exposure assessment. For this reason, the available data for fish and wildlife were evaluated for possible inclusion in the WHO-UNEP TEF concept, along with the chlorinated congeners as published earlier van den Berg et al.

For this purpose, only REPs from fish larvae studies are available for the brominated compounds.

ARCHIVED - Polychlorinated Dibenzodioxins and Polychlorinated Dibenzofurans - PSL1

These indicate that there may be significant differences between the SARs of REPs for fish early life stage toxicity for both brominated and chlorinated congeners. Instead, it is recommended that regulatory agencies consider the use of REPs provided in Table 1 for the use of ecotoxicological risk assessment in the aquatic environment. This is comparable to the inherent uncertainty of one order of magnitude in the present WHO TEF approach for dl-like chlorinated compounds.

Based on the considerations discussed above, the use of similar interim TEF values for brominated and chlorinated congeners for human risk assessment is recommended by the WHO and UNEP, pending availability of future studies on these compounds. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Article Navigation. Close mobile search navigation Article Navigation.

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Contaminants in fish tissue from US lakes and reservoirs: a national probabilistic study

E-mail: m. Oxford Academic. Google Scholar. Michael S.

CLARC - Washington State Department of Ecology

Linda S. Michael J.

Heidelore Fiedler. Jerzy Falandysz. Martin Rose. Dieter Schrenk. Stephen Safe. Chiharu Tohyama. Angelika Tritscher. Mats Tysklind. Richard E. Cite Citation. Permissions Icon Permissions. Open in new tab Download slide. Table 1. Open in new tab. Search ADS.

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In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice. Occurrence of polybrominated biphenyls, polybrominated dibenzo-p-dioxins, and polybrominated dibenzofurans as impurities in commercial polybrominated diphenyl ether mixtures. Toxic equivalency factors of polybrominated dibenzo-p-dioxin, dibenzofuran, biphenyl, and polyhalogenated diphenyl ether congeners based on rainbow trout early life stage mortality. Additive interactions between pairs of polybrominated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners in a rainbow trout early life stage mortality bioassay.

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